Study of the Influence of the Duration of Bisphosphonate Intake on the Outcome of Bisphosphonate-associated Osteonecrosis of the Jaws Treatment Using Statistical Method Logistic Regression

Abstract

Bisphosphonates are a group of drugs that are widely used in the treatment of osteoclast-mediated diseases related to bone loss. Since 2003 the problem of bisphosphonate-associated osteonecrosis of the jaws (BAONJ) has been raised, and many authors have published the cases they have observed. BAONJ is a multifactorial disease, and the risk factors for the development of the disease can be divided into those related to bisphosphonate therapy, local risk factors, demographic and systemic factors, genetic factors and preventive factors.

The aim of the present study is to determine the effect of the duration of bisphosphonate intake on the outcome of bisphosphonate-associated osteonecrosis of the jaws (BAONJ) treatment using the statistical method one-dimensional logistic regression which is from the direction of regression analysis. In the present study we included 44 patients diagnosed with Bisphosphonate-associated osteonecrosis of the jaw (BAONJ). For each patient included in the study, information on the anamnesis, general and local status and results of clinical and paraclinical studies is recorded in an individual card.

Our study shows that with the increase of the duration of BF intake, the likelihood of disease progression also increases, found in the examination of the patient on the first and on the sixth month after the treatment of BAONJ. Therefore, we can conclude that the factor duration of BF intake can be used as a predictor of the outcome of BAONJ treatment, and with increasing of its value, the likelihood of disease progression increases. Furthermore, we can suggest that the duration of bisphosphonate intake is an important