Circulating miRNAs – a Potential Non-invasive Biomarker for Diagnosis of Endometriosis

Authors

  • Victoria Spasova Medical University of Sofia, Bulgaria
  • Zora Hammoudeh Acibadem City Clinic UMHAT “Tokuda", Bulgaria
  • Olga Antonova Medical University of Sofia, Bulgaria
  • Liliya Koleva UMHATEM “Pirogov” and University Hospital “Sofiamed”, Bulgaria
  • Draga Toncheva Bulgarian Academy of Sciences
  • Savina Hadjidekova Medical University of Sofia, Bulgaria
  • Anatoli Kolev Medical University of Sofia, Bulgaria
  • Diana Hristova UMHAT “Aleksandrovska” and National Center for Infectious and Parasitic Diseases, Bulgaria
  • Ventsisava Pencheva UMHAT “Aleksandrovska” and Medical University of Sofia, Bulgaria
  • Stanislava Hitrova University Hospital of Obstetrics and Gynecology “Maichin dom” and Medical University of Sofia, Bulgaria
  • Manol Sokolov UMHAT “Aleksandrovska” and Medical University of Sofia, Bulgaria
  • Dejan Korunoski UMHATEM “Pirogov”, Bulgaria
  • Valentina Petkova Medical University of Sofia, Bulgaria
  • Milen Dimitrov Medical University of Sofia, Bulgaria
  • Silvia Nikolova Medical University of Sofia, Bulgaria
  • Vesela Karamisheva Medical University of Sofia and University Hospital of Obstetrics and Gynecology “Maichin dom”, Bulgaria

DOI:

https://doi.org/10.7546/CRABS.2024.12.09

Keywords:

endometriosis, diagnosis, biomarker, miRNA

Abstract

Endometriosis is a debilitating disease affecting one in ten women worldwide. Due to several reasons the diagnosis is delayed for 7–11 years. Currently, the ultimate diagnostic procedure is laparoscopy followed by histological examination. The need for non-invasive biomarker is placed as a top priority according to the World Endometriosis Society.

The present study includes 45 females – 30 patients with endometriosis at different stages and 15 healthy controls. An expression analysis of 84 circulating miRNAs was performed comparing between different groups of participants. Ten miRNAs with the most significant expression difference between females at early stage of endometriosis, advanced stage of endometriosis and healthy controls were nominated as a potential diagnostic and prognostic biomarker using a panel of miRNAs.

Author Biographies

Victoria Spasova, Medical University of Sofia, Bulgaria

Mailing Address:
Department of Medical Genetics,
Faculty of Medicine,
Medical University of Sofia,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

E-mail: vic.spasova@gmail.com

Zora Hammoudeh, Acibadem City Clinic UMHAT “Tokuda", Bulgaria

Mailing Address:
Clinical Laboratory, Acibadem City Clinic UMHAT “Tokuda",
51В Nikola Vaptsarov Blvd,
1407 Sofia, Bulgaria

E-mail: zorahammoudeh@gmail.com

Olga Antonova, Medical University of Sofia, Bulgaria

Mailing Address:
Department of Medical Genetics,
Faculty of Medicine,
Medical University of Sofia,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

E-mail: drolgaantonova@gmail.com

Liliya Koleva, UMHATEM “Pirogov” and University Hospital “Sofiamed”, Bulgaria

Mailing Addresses:
Clinic of Operative Gynecology, UMHATEM “Pirogov”,
21 Totleben Blvd, 1606 Sofia, Bulgaria

and

Clinic of Obstetrics and Gynecology, University Hospital “Sofiamed”,
16 G. M. Dimitrov Blvd, 1431, Sofia, Bulgaria

E-mail: liliaivanova76@mail.bg

Draga Toncheva, Bulgarian Academy of Sciences

Mailing Address:
Bulgarian Academy of Sciences,
1 November 15th St, 1000 Sofia, Bulgaria

E-mail: dragatoncheva@gmail.com

Savina Hadjidekova, Medical University of Sofia, Bulgaria

Mailing Address:
Department of Medical Genetics,
Faculty of Medicine,
Medical University of Sofia,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

E-mails: svhadjidekova@medfac.mu-sofia.bg, hadjidekova_sav@abv.bg

Anatoli Kolev, Medical University of Sofia, Bulgaria

Mailing Address:
Faculty of Medicine,
Medical University of Sofia,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

E-mail: anatoli.kolev5@gmail.com

Diana Hristova, UMHAT “Aleksandrovska” and National Center for Infectious and Parasitic Diseases, Bulgaria

Mailing Addresses:
UMHAT “Aleksandrovska”,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

and

National Center for Infectious and Parasitic Diseases,
26 Yanko Sakazov Blvd, Sofia, Bulgaria

E-mail: did_hris@abv.bg

Ventsisava Pencheva, UMHAT “Aleksandrovska” and Medical University of Sofia, Bulgaria

Mailing Addresses:
UMHAT “Aleksandrovska”,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

and

Department of Internal Medicine,
Faculty of Medicine,
Medical University of Sofia,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

E-mail: Pencheva.bg@abv.bg

Stanislava Hitrova, University Hospital of Obstetrics and Gynecology “Maichin dom” and Medical University of Sofia, Bulgaria

Mailing Addresses:
Clinic of Neonatology,
University Hospital of Obstetrics and Gynecology “Maichin dom”,
2 Zdrave St, 1431 Sofia, Bulgaria

and

Department of Obstetrics and Gynecology,
Faculty of Medicine,
Medical University of Sofia,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

E-mail: stasia_doc@abv.bg

Manol Sokolov, UMHAT “Aleksandrovska” and Medical University of Sofia, Bulgaria

Mailing Addresses:
UMHAT “Aleksandrovska”,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

Department of Surgery,
Faculty of Medicine,
Medical University of Sofia,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

E-mail: msokolov@medfac.mu-sofia.bg

Dejan Korunoski, UMHATEM “Pirogov”, Bulgaria

Mailing Address:
Department of Surgery,
UMHATEM “Pirogov”,
21 Totleben Blvd, 1606 Sofia, Bulgaria

E-mail: ykornovski@abv.bg

Valentina Petkova, Medical University of Sofia, Bulgaria

Mailing Address:
Faculty of Pharmacy,
Medical University of Sofia,
2 Dunav St, Sofia, Bulgaria

E-mail: petkovav1972@gmail.com

Milen Dimitrov, Medical University of Sofia, Bulgaria

Mailing Address:
Faculty of Pharmacy,
Medical University of Sofia,
2 Dunav St, Sofia, Bulgaria

E-mail: mdimitrov@pharmfac.mu-sofia.bg

Silvia Nikolova, Medical University of Sofia, Bulgaria

Mailing Address:
Faculty of Medicine,
Medical University of Sofia,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

E-mail: 102285@students.mu-sofia.bg

Vesela Karamisheva, Medical University of Sofia and University Hospital of Obstetrics and Gynecology “Maichin dom”, Bulgaria

Mailing Addresses:
Department of Obstetrics and Gynecology,
Faculty of Medicine,
Medical University of Sofia,
1 St. Georgi Sofiiski St, 1431 Sofia, Bulgaria

and

Second Gynecology Clinic,
University Hospital of Obstetrics and Gynecology “Maichin dom”,
2 Zdrave St, 1431 Sofia, Bulgaria

E-mail: vkaramisheva@abv.bg

Downloads

Published

25-12-2024

How to Cite

[1]
V. Spasova, “Circulating miRNAs – a Potential Non-invasive Biomarker for Diagnosis of Endometriosis”, C. R. Acad. Bulg. Sci., vol. 77, no. 12, pp. 1808–1816, Dec. 2024.

Issue

Vol. 77 No. 12 (2024)

Section

Medicine

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