Impact of Different Infertility Diagnoses on the Cost of Ovarian Hyperstimulation and Clinical Outcomes in IVF/ICSI Cycles

Abstract

The aim of this study was to analyze the impact of different infertility diagnoses on the cost of ovarian stimulation and clinical outcomes in IVF/ICSI cycles. The study was performed in specialized gynecology clinic in Bulgaria and included 640 patients undergoing IVF/ICSI cycles during the period 2016--2020. We found that there were statistically significant differences in mean controlled ovarian hyperstimulation (COH) cost for male factor, tubal factor, and unexplained infertility. The results have shown that the cost of COH statistically differs for male factor patients without live birth. In terms of IVF/ICSI outcomes, the results demonstrate that clinical pregnancies and live births depend on infertility reason. In conclusion, the cost of COH therapy depends on infertility reasons and differs for groups with achieved clinical pregnancies and live births. There was an evidence that higher cost is connected with higher birth rate and lower miscarriages but it strongly depends on infertility reasons.