Evaluating the in Vitro Biological Efficacy of Novel Ketoprofen Hybrids against Inflammation, Arthritis, and Oxidative Stress

Authors

  • Stanimir Manolov Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria
  • Dimitar Bojilov Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria
  • Iliyan Ivanov Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria

DOI:

https://doi.org/10.7546/CRABS.2024.06.05

Keywords:

ketoprofen, hybrid molecules, HPSA, IAD, ATA, in vitro, in silico

Abstract

In this study, we disclose the outcomes of the biological assessment of recently synthesized hybrids of ketoprofen with 2-phenylethylamines and 1,2,3,4-tetrahydroisoquinolines. These hybrids were obtained using an environmentally friendly method that minimizes the generation of waste products. The newly acquired hybrids were analysed to evaluate their antioxidant, anti-inflammatory, and anti-arthritic activities. Additionally, as potential drugs exhibiting favourable results, their experimental partition coefficient in a biphasic system of lipids and water (logP) was determined.

Author Biographies

Stanimir Manolov, Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria

Mailing Address:
Department of Organic Chemistry,
Faculty of Chemistry,
University of Plovdiv “Paisii Hilendarski”
24 Tzar Asen St
4000 Plovdiv, Bulgaria

Email: manolov@uni-plovdiv.bg

Dimitar Bojilov, Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria

Mailing Address:
Department of Organic Chemistry,
Faculty of Chemistry,
University of Plovdiv “Paisii Hilendarski”
24 Tzar Asen St
4000 Plovdiv, Bulgaria

Email: mbojilov@gmail.com

Iliyan Ivanov, Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Bulgaria

Mailing Address:
Department of Organic Chemistry,
Faculty of Chemistry,
University of Plovdiv “Paisii Hilendarski”
24 Tzar Asen St
4000 Plovdiv, Bulgaria

Email: iiiliyan@abv.bg

Downloads

Published

30-06-2024

How to Cite

[1]
S. Manolov, D. Bojilov, and I. Ivanov, “Evaluating the in Vitro Biological Efficacy of Novel Ketoprofen Hybrids against Inflammation, Arthritis, and Oxidative Stress”, C. R. Acad. Bulg. Sci. , vol. 77, no. 6, pp. 824–830, Jun. 2024.

Issue

Vol. 77 No. 6 (2024)

Section

Biology

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