Anti-cyclic Citrullinated Peptide Antibody and Rheumatoid Factor and the Relationship between Periodontitis and Rheumatoid Arthritis

Authors

  • Theodora Nikolaeva Bolyarova-Konova Department of Periodontology, Faculty of Dental Medicine, Medical University – Sofia
  • Lyubomir Deyanov Stefanov Department of Periodontology, Faculty of Dental Medicine, Medical University – Sofia
  • Zlatimir Gospodinov Kolarov Clinic of Rheumatology, University Hospital “St. Ivan Rilski”, Faculty of Medicine, Medical University – Sofia
  • Radoslava Emilova Grozdanova National Reference Laboratory of Immunology, National Center of Infectious and Parasitic Diseases
  • Maria Hristianova Nikolova National Reference Laboratory of Immunology, National Center of Infectious and Parasitic Diseases

DOI:

https://doi.org/10.7546/CRABS.2022.03.16

Keywords:

chronic periodontitis, rheumatoid arthritis, rheumatic factor, anti-cyclic citrullinated peptide antibody

Abstract

The purpose of this study is to determine the concentration of Rheumatic Factor (RF) and Anti-cyclic Citrullinated Peptide Antibody (ACPA) in serum and in Gingival Crevicular Fluid (GCF) and their dependence on the presence of periodontitis (P) and rheumatoid arthritis (RA). The study involved 81 patients divided into three groups: Group I – patients with P and without RA (with osteoarthritis) – 26 subjects; Group II – patients with P and RA – 30 subjects; Group III – patients with periodontal health (without P) and RA – 25 subjects. For all patients the levels of ACPA and RF (class IgM) have been analyzed by ELISA in serum and GCF. We found a significantly higher incidence of ACPA in the GCF positive individuals and significantly higher mean ACPA values in GCF in Group II patients compared to patients in Group I. We found a significant difference between the frequency of RF in the GCF positive patients in Group II compared to those in Group I as well as the RF in the GCF positive patients in Group II compared to those in Group III. In the study among the patients of Group II we found a significant correlation between the RF and ACPA concentrations in serum and the number of lost teeth. These results are associated with possible enhanced extraarticular synthesis of ACPA and RF in the periodontal tissues in patients with periodontitis and predisposed to RA. Evidence for the effect of RA on periodontitis is the correlation between the concentration of ACPA and RF in serum – biomarkers for RA and the number of lost teeth. 

Author Biographies

Theodora Nikolaeva Bolyarova-Konova, Department of Periodontology, Faculty of Dental Medicine, Medical University – Sofia

Mailing Address:
Department of Periodontology,
Faculty of Dental Medicine,
Medical University – Sofia
1, St. G. Sofiiski Blvd
1431 Sofia, Bulgaria

E-mail: t_bolyarova@abv.bg

Lyubomir Deyanov Stefanov, Department of Periodontology, Faculty of Dental Medicine, Medical University – Sofia

Mailing Address:
Department of Periodontology,
Faculty of Dental Medicine,
Medical University – Sofia
1, St. G. Sofiiski Blvd
1431 Sofia, Bulgaria

E-mail: stefanov.lubomir@gmail.com

Zlatimir Gospodinov Kolarov, Clinic of Rheumatology, University Hospital “St. Ivan Rilski”, Faculty of Medicine, Medical University – Sofia

Mailing Address:
Clinic of Rheumatology,
University Hospital “St. Ivan Rilski”,
Faculty of Medicine,
Medical University – Sofia
13, Urvich St
1612 Sofia, Bulgaria

E-mail: zkolarov@abv.bg

Radoslava Emilova Grozdanova, National Reference Laboratory of Immunology, National Center of Infectious and Parasitic Diseases

Mailing Address:
National Reference Laboratory of Immunology,
National Center of Infectious and Parasitic Diseases
26, Yanko Sakazov Blvd
1504 Sofia, Bulgaria

E-mail: reantova@abv.bg

Maria Hristianova Nikolova, National Reference Laboratory of Immunology, National Center of Infectious and Parasitic Diseases

Mailing Address:
National Reference Laboratory of Immunology,
National Center of Infectious and Parasitic Diseases
26, Yanko Sakazov Blvd
1504 Sofia, Bulgaria

E-mail: mstoimenova@ncipd.org 

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Published

27-03-2022

How to Cite

[1]
T. Bolyarova-Konova, L. Stefanov, Z. Kolarov, R. Grozdanova, and M. Nikolova, “Anti-cyclic Citrullinated Peptide Antibody and Rheumatoid Factor and the Relationship between Periodontitis and Rheumatoid Arthritis”, C. R. Acad. Bulg. Sci. , vol. 75, no. 3, pp. 451–457, Mar. 2022.

Issue

Section

Medicine