Protective Effect of Turmeric against Aluminium-induced Prostate Damage in Rats

Authors

  • Farouk Boudou Department of Biology, Faculty of Natural and Life Sciences, Djillali Liabes University of Sidi-Bel-Abbes, Algeria
  • Amal Belakredar Department of Environmental Sciences, Faculty of Natural and Life Sciences, Djillali Liabes University Sidi-Bel-Abbès, Algeria
  • Malika Bendahmane-Salmi Research Laboratory of Environment and Health, Faculty of Medicine, Sidi-Bel-Abbes, Algeria

DOI:

https://doi.org/10.7546/CRABS.2024.03.16

Keywords:

aluminium toxicity, antioxidant, anti-inflammatory, prostate damage, turmeric

Abstract

This study investigates the potential protective properties of turmeric (Curcuma longa L.) against aluminium (Al) toxicity-induced prostate damage in male rats. The administration of AlCl3 to rats resulted in decreased body weight, increased oxidative stress markers, hormonal depletion, apoptosis induction, and pro-inflammatory cell infiltration in the prostate tissue. Additionally, histopathological examination revealed various abnormalities. However, co-treatment with turmeric extract improved body weight, increased testosterone levels, reduced apoptosis, and mast cell infiltration. C. longa L. exhibited strong antioxidant and anti-inflammatory effects, highlighting its potential as a phytomedicine against reproductive disorders like prostatitis induced by Al exposure.

Author Biographies

Farouk Boudou, Department of Biology, Faculty of Natural and Life Sciences, Djillali Liabes University of Sidi-Bel-Abbes, Algeria

Mailing Address:
Department of Biology,
Faculty of Natural and Life Sciences,
Djillali Liabes University of Sidi-Bel-Abbes,
Sidi-Bel-Abbes, Algeria

E-mail: farouk.boudou@yahoo.fr

Amal Belakredar, Department of Environmental Sciences, Faculty of Natural and Life Sciences, Djillali Liabes University Sidi-Bel-Abbès, Algeria

Mailing Address:
Department of Environmental Sciences,
Faculty of Natural and Life Sciences,
Djillali Liabes University Sidi-Bel-Abbès,
BP 89, 22000 Sidi-Bel-Abbès, Algeria

E-mail: belakredar-amel@hotmail.fr

Malika Bendahmane-Salmi, Research Laboratory of Environment and Health, Faculty of Medicine, Sidi-Bel-Abbes, Algeria

Mailing Address:
Research Laboratory of Environment and Health (RLEH),
Faculty of Medicine,
Sidi-Bel-Abbes, Algeria

E-mail: maliabendaman@gmail.com

Downloads

Published

31-03-2024

How to Cite

[1]
F. Boudou, A. Belakredar, and M. Bendahmane-Salmi, “Protective Effect of Turmeric against Aluminium-induced Prostate Damage in Rats”, C. R. Acad. Bulg. Sci. , vol. 77, no. 3, pp. 451–458, Mar. 2024.

Issue

Section

Medicine