Protective Effect of Turmeric against Aluminium-induced Prostate Damage in Rats

Abstract

This study investigates the potential protective properties of turmeric (Curcuma longa L.) against aluminium (Al) toxicity-induced prostate damage in male rats. The administration of AlCl₃ to rats resulted in decreased body weight, increased oxidative stress markers, hormonal depletion, apoptosis induction, and pro-inflammatory cell infiltration in the prostate tissue. Additionally, histopathological examination revealed various abnormalities. However, co-treatment with turmeric extract improved body weight, increased testosterone levels, reduced apoptosis, and mast cell infiltration. C. longa L. exhibited strong antioxidant and anti-inflammatory effects, highlighting its potential as a phytomedicine against reproductive disorders like prostatitis induced by Al exposure.