Serum Fructosamine as a Marker for Glycemic Control in Patients with Diabetic Nephropathy

Authors

  • Bilyana Vasileva University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria
  • Evan Gatev Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences
  • Aleksander Aleksandrov Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences
  • Simona Kerezieva University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria
  • Siyana Ilieva University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria
  • Daniela Popova University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria
  • Vasil Vasilev University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria
  • Toshimitsu Niwa
  • Roumyana Mironova Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences
  • Boryana Deliyska University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria
  • Rositsa Tsekovska Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences

DOI:

https://doi.org/10.7546/CRABS.2024.03.15

Keywords:

diabetic nephropathy, fructosamine, glycemic control

Abstract

Diabetes mellitus (DM) is a metabolic disease of chronic insulin deficiency or resistance. The progression of DM is associated with long-term damage to macro- and micro-vascular body systems and causes serious health complications. Up to 40% of DM patients develop chronic kidney disease (CKD), mainly as a consequence of diabetic nephropathy (DN). Hence, strict glycemic control is recommended to slow down CKD progression. Hyperglycemia causes complications in diabetic patients through the glycation of various proteins. The interaction of glucose with the free NH2 groups of proteins results in the formation of the early glycation product fructosamine (FA). FA has a short half-life (1 to 2 weeks) and hence it has the potential of an early marker for glycemic control. Although long used in the clinical practice, the FA diagnostic and prognostic significance remains questionable. In this study, we tested the FA potential to serve as a glycemic marker in DM patients with DN. We found that DM patients have significantly higher serum FA levels than non-diabetics. Further, the serum FA level in diabetics correlates positively with the blood glucose concentration. Finally, the mean serum FA level was higher in DM patients with DN, compared to those without DN. These results establish FA as a promising marker for glycemic control in DN patients.

Author Biographies

Bilyana Vasileva, University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria

Mailing Address:
University Hospital “Tsaritsa Yoanna-ISUL”,
8 Byalo more St,
1527 Sofia, Bulgaria

E-mail: b_vasileva_vr@abv.bg

Evan Gatev, Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences

Mailing Address:
Roumen Tsanev Institute of Molecular Biology,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 21,
1113 Sofia, Bulgaria

E-mail: evan_gatev@sfu.ca

Aleksander Aleksandrov, Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences

Mailing Address:
Roumen Tsanev Institute of Molecular Biology,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 21,
1113 Sofia, Bulgaria

E-mail: aleksander_aleksandrov@proton.me

Simona Kerezieva, University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria

Mailing Address:
University Hospital “Tsaritsa Yoanna-ISUL”,
8 Byalo more St,
1527 Sofia, Bulgaria

E-mail: dr.kerezieva@gmail.com

Siyana Ilieva, University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria

Mailing Address:
University Hospital “Tsaritsa Yoanna-ISUL”,
8 Byalo more St,
1527 Sofia, Bulgaria

E-mail: siyana9696@abv.bg

Daniela Popova, University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria

Mailing Address:
University Hospital “Tsaritsa Yoanna-ISUL”,
8 Byalo more St,
1527 Sofia, Bulgaria

E-mail: danielapopovabg@yahoo.com

Vasil Vasilev, University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria

Mailing Address:
University Hospital “Tsaritsa Yoanna-ISUL”,
8 Byalo more St,
1527 Sofia, Bulgaria

E-mail: w_wasilev@yahoo.com

Toshimitsu Niwa

Mailing Address:
Shubun University and Shubun University Junior College
6 Nikkocho, Ichinomiya, Aichi
491-0938, Japan

E-mail: niwa.t@shubun.ac.jp

Roumyana Mironova, Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences

Mailing Address:
Roumen Tsanev Institute of Molecular Biology,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 21,
1113 Sofia, Bulgaria

E-mail: rumym@bio21.bas.bg

Boryana Deliyska, University Hospital “Tsaritsa Yoanna-ISUL”, Bulgaria

Mailing Address:
University Hospital “Tsaritsa Yoanna-ISUL”,
8 Byalo more St,
1527 Sofia, Bulgaria

E-mail: delijska10@yahoo.com

Rositsa Tsekovska, Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences

Mailing Address:
Roumen Tsanev Institute of Molecular Biology,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 21,
1113 Sofia, Bulgaria

E-mail: rcekovska@gmail.com

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Published

31-03-2024

How to Cite

[1]
B. Vasileva, “Serum Fructosamine as a Marker for Glycemic Control in Patients with Diabetic Nephropathy”, C. R. Acad. Bulg. Sci. , vol. 77, no. 3, pp. 442–450, Mar. 2024.

Issue

Section

Medicine