Hepatoprotective Effect of Anvillea radiata Aqueous Extract against Carbon Tetrachloride-Induced Injury in Rats

Authors

  • Amal Belakredar Department of Environmental Sciences, Faculty of Nature and Life Sciences, Djillali LIABES University Sidi-Bel-Abbès, Algeria
  • Farouk Boudou Department of Biology, Faculty of Sciences, Djillali LIABES University Sidi-Bel-Abbès, Algeria
  • Narimane Taibi Department of Biology, Faculty of Sciences, University Dr. Tahar Moulay de Saida, Algeria
  • Kadda Hachem Department of Biology, Faculty of Sciences, University Dr. Tahar Moulay de Saida, Algeria
  • Yasmina Benabdesslem Department of Biology, Faculty of Sciences, University Dr. Tahar Moulay de Saida, Algeria

DOI:

https://doi.org/10.7546/CRABS.2024.03.06

Keywords:

Anvillea radiata, hepatoprotection, nephroprotection, carbon tetrachloride, histopathology

Abstract

The present study aimed to assess the hepatoprotective property of Anvillea radiata aqueous extract (AAE) against carbon tetrachloride (CCl4)-induced liver injury in rats. Twenty rats were divided into four groups: the control group received no treatment; the second group received a 1 ml dose of CCl4 (30%) orally; the third received a 1 ml dose of CCl4 (30%) orally and AAE at a dosage of 40 mg per kilogram of body weight; the fourth group received AAE alone at the same dose. The results indicated that co-exposure to CCl4 and AAE significantly improved hepatic enzyme markers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), compared to the CCl4-exposed group. Histological examinations demonstrated that AAE preserved the normal architecture of hepatocytes. In conclusion, Anvillea radiata exhibits notable hepatoprotective property against CCl4-induced toxicity in rats.

Author Biographies

Amal Belakredar, Department of Environmental Sciences, Faculty of Nature and Life Sciences, Djillali LIABES University Sidi-Bel-Abbès, Algeria

Mailing Address:
Department of Environmental Sciences,
Faculty of Nature and Life Sciences,
Djillali LIABES University Sidi-Bel-Abbès
BP 89, 22000 Sidi-Bel-Abbès – Algeria

E-mail: belakredar-amel@hotmail.fr

Farouk Boudou, Department of Biology, Faculty of Sciences, Djillali LIABES University Sidi-Bel-Abbès, Algeria

Mailing Address:
Department of Biology,
Faculty of Sciences,
Djillali LIABES University Sidi-Bel-Abbès,
BP 89, 22000 Sidi-Bel-Abbès – Algeria

E-mail: farouk.boudou@yahoo.fr

Narimane Taibi, Department of Biology, Faculty of Sciences, University Dr. Tahar Moulay de Saida, Algeria

Mailing Address:
Department of Biology,
Faculty of Sciences,
University Dr. Tahar Moulay de Saida
BP 138 cited ENNASR, 20000 Saida – Algeria

E-mail: narimane_bio@yahoo.fr

Kadda Hachem, Department of Biology, Faculty of Sciences, University Dr. Tahar Moulay de Saida, Algeria

Mailing Address:
Department of Biology,
Faculty of Sciences,
University Dr. Tahar Moulay de Saida
BP 138 cited ENNASR, 20000 Saida – Algeria

E-mail: kadda46@hotmail.com

Yasmina Benabdesslem, Department of Biology, Faculty of Sciences, University Dr. Tahar Moulay de Saida, Algeria

Mailing Address:
Department of Biology,
Faculty of Sciences,
University Dr. Tahar Moulay de Saida
BP 138 cited ENNASR, 20000 Saida – Algeria

E-mail: yasmin46@live.fr

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Published

31-03-2024

How to Cite

[1]
A. Belakredar, F. Boudou, N. Taibi, K. Hachem, and Y. Benabdesslem, “Hepatoprotective Effect of Anvillea radiata Aqueous Extract against Carbon Tetrachloride-Induced Injury in Rats”, C. R. Acad. Bulg. Sci. , vol. 77, no. 3, pp. 363–369, Mar. 2024.

Issue

Section

Biology