Hepatoprotective Effect of Anvillea radiata Aqueous Extract against Carbon Tetrachloride-Induced Injury in Rats

Abstract

The present study aimed to assess the hepatoprotective property of Anvillea radiata aqueous extract (AAE) against carbon tetrachloride (CCl₄)-induced liver injury in rats. Twenty rats were divided into four groups: the control group received no treatment; the second group received a 1 ml dose of CCl₄ (30%) orally; the third received a 1 ml dose of CCl₄ (30%) orally and AAE at a dosage of 40 mg per kilogram of body weight; the fourth group received AAE alone at the same dose. The results indicated that co-exposure to CCl₄ and AAE significantly improved hepatic enzyme markers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), compared to the CCl₄-exposed group. Histological examinations demonstrated that AAE preserved the normal architecture of hepatocytes. In conclusion, Anvillea radiata exhibits notable hepatoprotective property against CCl₄-induced toxicity in rats.