Pulmonary Bacterial Pathogens in Patients with Cystic Fibrosis

Authors

  • Nadia Kolarova-Yaneva Department of Paediatrics, Medical University of Sofia, Bulgaria
  • Valentina Edreva Department of Microbiology, Virology and Medical Genetics, Medical University of Pleven, Bulgaria
  • Nikolay Yanev Department of Pulmonary Diseases, Medical University of Sofia, Bulgaria
  • Lyubomir Beshev Department of Surgery, Medical University of Pleven, Bulgaria
  • Vania Nedkova Department of Paediatrics, Medical University of Pleven, Bulgaria

DOI:

https://doi.org/10.7546/CRABS.2024.01.13

Keywords:

cystic fibrosis, infections, aetiology, S. aureus, P. aeruginosa

Abstract

The aim of the research is to perform microbiological analysis of respiratory tract samples in patients with cystic fibrosis and to verify the aetiology, prevalence and antibiotic sensitivity of the isolated pathogens.

Sixteen patients with cystic fibrosis aged from 3 months to 30 years were included. Twenty-nine respiratory and one digestive tract samples were tested. The identification of isolated pathogens was performed using conventional\break methods and automated miniAPI and VITEK 2 systems (bioMerieux, France). Antibiotic sensitivity of all isolates was determined by a disk diffusion test or the minimum inhibitory concentration method.

A total of 34 microbial strains from 15 patients were isolated: Gram-positive bacteria 12 (35.29%), Gram-negative bacteria 20 (58.82%) and yeast-like fungi 2 (5.88%). S. aureus is the dominant pathogen among Gram-positive bacteria. Most of the Gram-negative bacteria are identified as P. aeruginosa and other non-fermenting glucose bacteria and the rest as H. influenzae and E. coli. P. aeruginosa was isolated from patients in different age groups. The strains showed good sensitivity to antibiotics.

Microorganisms isolated from the respiratory tract in patient with cystic fibrosis vary over the period of follow-up. Gram-negative bacteria, especially P. aeruginosa, are dominant but showed good sensitivity to antimicrobial agents and no multidrug-resistant strains were isolated.

Author Biographies

Nadia Kolarova-Yaneva, Department of Paediatrics, Medical University of Sofia, Bulgaria

Mailing Address:
Department of Paediatrics,
Medical University of Sofia
15 Akademik Ivan Evstratiev Geshov Blvd,
1431 Sofia, Bulgaria

E-mail: nadia.kolarova.yaneva@gmail.com

Valentina Edreva, Department of Microbiology, Virology and Medical Genetics, Medical University of Pleven, Bulgaria

Mailing Address:
Department of Microbiology, Virology and Medical Genetics,
Medical University of Pleven
1 St. Kliment Ohridski St, 5800 Pleven, Bulgaria

E-mail: valenedreva@gmail.com

Nikolay Yanev, Department of Pulmonary Diseases, Medical University of Sofia, Bulgaria

Mailing Address:
Department of Pulmonary Diseases,
Medical University of Sofia
19 Akademik Ivan Evstratiev Geshov Blvd,
1413 Sofia, Bulgaria

E-mail: dr.nikolay.yanev@gmail.com

Lyubomir Beshev, Department of Surgery, Medical University of Pleven, Bulgaria

Mailing Address:
Department of Surgery,
Medical University of Pleven
1 St. Kliment Ohridski St,
5800 Pleven, Bulgaria

E-mail: docbeshev@abv.bg

Vania Nedkova, Department of Paediatrics, Medical University of Pleven, Bulgaria

Mailing Address:
Department of Paediatrics,
Medical University of Pleven
8A Georgi Kochev St, 5800 Pleven, Bulgaria

E_mail: doc_vania_nedkova@yahoo.com

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Published

29-01-2024

How to Cite

[1]
N. Kolarova-Yaneva, V. Edreva, N. Yanev, L. Beshev, and V. Nedkova, “Pulmonary Bacterial Pathogens in Patients with Cystic Fibrosis”, C. R. Acad. Bulg. Sci. , vol. 77, no. 1, pp. 111–117, Jan. 2024.

Issue

Section

Medicine