Role of Extended Family for Intrafamilial Transmission of Helicobacter pylori Infection in Bulgarian Children

Authors

  • Petyo Hadzhiyski Department of Pediatric Gastroenterology, Medical Faculty, Medical University - Sofia, Bulgaria
  • Mila Baycheva Department of Pediatric Gastroenterology, Medical Faculty, Medical University - Sofia, Bulgaria
  • Rayna Shentova-Eneva Department of Pediatric Gastroenterology, Medical Faculty, Medical University - Sofia, Bulgaria
  • Denitza Kofinova Department of Pediatric Gastroenterology, Medical Faculty, Medical University - Sofia, Bulgaria
  • Rumyana Markovska Department of Medical Microbiology, Medical Faculty, Medical University - Sofia, Bulgaria
  • Ivan Mitov Department of Medical Microbiology, Medical Faculty, Medical University - Sofia, Bulgaria
  • Lyudmila Boyanova Department of Medical Microbiology, Medical Faculty, Medical University - Sofia, Bulgaria

DOI:

https://doi.org/10.7546/CRABS.2023.11.14

Keywords:

Helicobacter pylori, family, children, diseases, infection, siblings, parents, grandparents

Abstract

Helicobacter pylori infection is one of the most common chronic bacterial infections worldwide. The infection is usually acquired during the first years of childhood and transmission from infected mother is considered an important epidemiological factor. The aim of this study was to assess the H. pylori positivity in Bulgarian symptomatic children in association with the presence or absence of family anamnesis of gastroduodenal diseases among their parents, siblings and grandparents. H. pylori infection was evaluated in 362 children in two groups: 181 children with family anamnesis of gastroduodenal diseases and 181 children without family anamnesis. All patients underwent esophagogastroduodenoscopy and gastric biopsy samples for microbiological examination for H. pylori were taken. H. pylori infection among children with family history of gastroduodenal diseases was significantly more frequent (69.1%) compared with the group of patients without a family anamnesis (21.0%, p <0.0001). In addition to the significance of the infected parents (69.4%) and siblings (52.0%), infected grandparents were also associated with high prevalence of the infection (77.8%, 21/27 cases) in the children. In conclusion, H. pylori infection among children with family history of gastroduodenal disease was 3.3-fold higher than that in the group without family anamnesis. The significance of the grandparents in the extended family households should be considered.

Author Biographies

Petyo Hadzhiyski, Department of Pediatric Gastroenterology, Medical Faculty, Medical University - Sofia, Bulgaria

Mailing Address:
Department of Pediatric Gastroenterology,
Medical Faculty,
Medical University - Sofia
11 Akad. Ivan Evstratiev Geshov Blvd
1612 Sofia, Bulgaria

E-mail: dr.hadjiiski@abv.bg

Mila Baycheva, Department of Pediatric Gastroenterology, Medical Faculty, Medical University - Sofia, Bulgaria

Mailing Address:
Department of Pediatric Gastroenterology,
Medical Faculty,
Medical University - Sofia
11 Akad. Ivan Evstratiev Geshov Blvd
1612 Sofia, Bulgaria

E-mail: mila.baycheva@gmail.com

Rayna Shentova-Eneva, Department of Pediatric Gastroenterology, Medical Faculty, Medical University - Sofia, Bulgaria

Mailing Address:
Department of Pediatric Gastroenterology,
Medical Faculty,
Medical University - Sofia
11 Akad. Ivan Evstratiev Geshov Blvd
1612 Sofia, Bulgaria

E-mail: rshentova@yahoo.com

Denitza Kofinova, Department of Pediatric Gastroenterology, Medical Faculty, Medical University - Sofia, Bulgaria

Mailing Address:
Department of Pediatric Gastroenterology,
Medical Faculty,
Medical University - Sofia
11 Akad. Ivan Evstratiev Geshov Blvd
1612 Sofia, Bulgaria

E-mail: kofinova@abv.bg

Rumyana Markovska, Department of Medical Microbiology, Medical Faculty, Medical University - Sofia, Bulgaria

Mailing Address:
Department of Medical Microbiology,
Medical Faculty,
Medical University - Sofia
2 Zdrave St
1431 Sofia, Bulgaria

E-mail: markovska73@abv.bg

Ivan Mitov, Department of Medical Microbiology, Medical Faculty, Medical University - Sofia, Bulgaria

Mailing Address:
Department of Medical Microbiology,
Medical Faculty,
Medical University - Sofia
2 Zdrave St
1431 Sofia, Bulgaria

E-mail: igmitov@gmail.com

Lyudmila Boyanova, Department of Medical Microbiology, Medical Faculty, Medical University - Sofia, Bulgaria

Mailing Address:
Department of Medical Microbiology,
Medical Faculty,
Medical University - Sofia
2 Zdrave St
1431 Sofia, Bulgaria

E-mail: l.boyanova@hotmail.com

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Published

27-11-2023

How to Cite

[1]
P. Hadzhiyski, “Role of Extended Family for Intrafamilial Transmission of Helicobacter pylori Infection in Bulgarian Children”, C. R. Acad. Bulg. Sci. , vol. 76, no. 11, pp. 1762–1767, Nov. 2023.

Issue

Section

Medicine