Effect of Newly Synthesized Methylxanthines on Motility, Fertilization Capacity of Male Gametes and Embryo Quality

Abstract

Male factor infertility affects 30--40% of the subfertile couples worldwide and that poses a significant medical and social issue. Different strategies are developed to increase the fertilization potential of male gametes during procedures of assisted reproduction. One of these approaches is the addition of biologically active molecules, which help to stimulate the motility of spermatozoa. In the current investigation, we analysed the effect of two newly synthesized original methylxanthines (N-61 and T-1) on the kinetic parameters of male gametes and compared it to the action of pentoxifylline (methylxanthine approved for utilization in clinical practice). It has been found that N-61 and T-1 increase the motility and the biological viability of spermatozoa, but do not influence their fertilization capacity and the quality of the obtained embryos.