Expression and Clinical Significance of Serum miR-1247-3p in Ischemic Stroke

Authors

  • Ai'hua Jiang Wuhan University of Science and Technology, China
  • Wenlong Wang Wuhan Rongjun hospital, China
  • Zifei Xiang Wuhan University of Science and Technology, China
  • Ming Zhu Department of Clinical Laboratory, China Resources Wuhan Steel General Hospital
  • Qiong Yuan Wuhan University of Science and Technology, China

DOI:

https://doi.org/10.7546/CRABS.2023.07.15

Keywords:

ischemic stroke, miR-1247-3p, biomarkers, serum

Abstract

To investigate the expression and clinical significance of serum miR-1247-3p in patients with ischemic stroke, twenty-five patients with ischemic stroke were collected, and twenty-five healthy individuals were used as controls. RT-qPCR measured the expression of serum miR-1247-3p. Logistic regression analysis was applied to evaluate the effect of influencing factors, including miR-1247-3p, on ischemic stroke. Spearman analysis was applied to study the relationship between miR-1247-3p and clinicopathological characteristics. The sensitivity and specificity of serum miR-1247-3p in the diagnosis of ischemic stroke were evaluated by ROC curves. Results show that serum miR-1247-3p levels were significantly lower in patients with ischemic stroke than in controls (< 0.001). miR-1247-3p expression levels negatively correlated with triglycerides (= –0.425, < 0.05). miR-1247-3p is a protective factor that can significantly influence the occurrence of ischemic stroke (OR, 0.401. 95% CI, 0.222–0.732; = 0.002). miR-1247-3p had a sensitivity of 92% and a specificity of 88% for the diagnosis of ischemic stroke. We conclude that serum miR-1247-3p expression levels are significantly reduced in patients with ischemic stroke and could serve as a potential biological marker for diagnosing ischemic stroke.

Author Biographies

Ai'hua Jiang, Wuhan University of Science and Technology, China

Mailing Address:
Wuhan University of Science and Technology
Wuhan, 430070, P. R. China

E-mail: jiangah132255@163.com

Wenlong Wang, Wuhan Rongjun hospital, China

Mailing Address:
Wuhan Rongjun hospital
Wuhan, 430079, P. R. China

E-mail: 2030465529@qq.com

Zifei Xiang, Wuhan University of Science and Technology, China

Mailing Address:
Wuhan University of Science and Technology
Wuhan, 430070, P. R. China

E-mail: xiangzifei@126.com

Ming Zhu, Department of Clinical Laboratory, China Resources Wuhan Steel General Hospital

Mailing Address:
Department of Clinical Laboratory,
China Resources Wuhan Steel General Hospital
Wuhan 430080, P. R. China

E-mail: 924353299@qq.com

Qiong Yuan, Wuhan University of Science and Technology, China

Mailing Address:
Wuhan University of Science and Technology
Wuhan, 430070, P. R. China

E-mail: yuanqiong@wust.edu.cn

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Published

31-07-2023

How to Cite

[1]
A. Jiang, W. Wang, Z. Xiang, M. Zhu, and Q. Yuan, “Expression and Clinical Significance of Serum miR-1247-3p in Ischemic Stroke”, C. R. Acad. Bulg. Sci. , vol. 76, no. 7, pp. 1111–1119, Jul. 2023.

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Section

Medicine