Effect of Non-surgical Periodontal Treatment on Lipoxin A4 Levels in Periodontitis Patients

Abstract

The aim of this study was to determine the lipoxin A₄ (LXA₄) in gingival crevicular fluid (GCF) and saliva in chronic periodontitis (CP) patients before and after non-surgical periodontal treatment (NSPT). A total of twenty subjects, ten patients with CP and ten healthy individuals were included in this study. Clinical measurements, GCF and saliva samples were obtained at the beginning and one month after NSPT. GCF and salivary LXA₄ were investigated by ELISA. Salivary LXA₄ were significantly higher in CP than in healthy subjects (p < 0.05), but no significant difference was observed after NSPT (p > 0.05). GCF LXA₄ were lower in CP and decreased after NSPT, but these differences were not significant (p > 0.05). However, GCF LXA₄ in post-treatment CP group were significantly lower than in healthy subjects (p < 0.05). Negative correlation was found between probing depth and GCF LXA₄ in CP group (r = −0.717; p < 0.05). Within the limitations of this study, LXA₄ might have a potential role in both the pathogenesis of periodontitis and the healing process.