Effect of Non-surgical Periodontal Treatment on Lipoxin A4 Levels in Periodontitis Patients

Authors

  • Еmrah Turkmen Department of Periodontology, Faculty of Dentistry, Istanbul Medipol University
  • Ceren Gokmenoglu Department of Periodontology, Faculty of Dentistry, Ordu University
  • Cankat Kara Department of Periodontology, Faculty of Dentistry, Ordu University
  • Figen Ongoz Dede Department of Periodontology, Faculty of Dentistry, Ordu University
  • Huriye Erbak Yılmaz Department of Medical Biochemistry, School of Medicine,  Ataturk Education and Research Hospital, Izmir Katip Celebi University
  • Varol Canakcı Department of Periodontology, Faculty of Dentistry, Ordu University

DOI:

https://doi.org/10.7546/CRABS.2022.02.15

Keywords:

gingival crevicular fluid, lipoxins, periodontitis, periodontal treatment, saliva

Abstract

The aim of this study was to determine the lipoxin A4 (LXA4) in gingival crevicular fluid (GCF) and saliva in chronic periodontitis (CP) patients before and after non-surgical periodontal treatment (NSPT). A total of twenty subjects, ten patients with CP and ten healthy individuals were included in this study. Clinical measurements, GCF and saliva samples were obtained at the beginning and one month after NSPT. GCF and salivary LXA4 were investigated by ELISA. Salivary LXA4 were significantly higher in CP than in healthy subjects (p < 0.05), but no significant difference was observed after NSPT (p > 0.05). GCF LXA4 were lower in CP and decreased after NSPT, but these differences were not significant (p > 0.05). However, GCF LXA4 in post-treatment CP group were significantly lower than in healthy subjects (p < 0.05). Negative correlation was found between probing depth and GCF LXA4 in CP group (r = −0.717; p < 0.05). Within the limitations of this study, LXA4 might have a potential role in both the pathogenesis of periodontitis and the healing process. 

Author Biographies

Еmrah Turkmen , Department of Periodontology, Faculty of Dentistry, Istanbul Medipol University

Department of Periodontology, Faculty of Dentistry,
Istanbul Medipol University
34810 Istanbul,
Turkey

emrahturkmen@medipol.edu.tr

Ceren Gokmenoglu, Department of Periodontology, Faculty of Dentistry, Ordu University

Department of Periodontology,
Faculty of Dentistry,
Ordu University
52200 Ordu,
Turkey

erdoganceren@yahoo.com

Cankat Kara, Department of Periodontology, Faculty of Dentistry, Ordu University

Department of Periodontology, Faculty of Dentistry,
Ordu University
52200 Ordu,
Turkey

mcankat@hotmail.com

Figen Ongoz Dede, Department of Periodontology, Faculty of Dentistry, Ordu University

Department of Periodontology, Faculty of Dentistry,
Ordu University
52200 Ordu,
Turkey

figen_ongoz@hotmail.com

Huriye Erbak Yılmaz, Department of Medical Biochemistry, School of Medicine,  Ataturk Education and Research Hospital, Izmir Katip Celebi University

Department of Medical Biochemistry, School of Medicine, 
Ataturk Education and Research Hospital,
Izmir Katip Celebi University
35360 Izmir,
Turkey

huriyeerbak@hotmail.com

Varol Canakcı, Department of Periodontology, Faculty of Dentistry, Ordu University

Department of Periodontology, Faculty of Dentistry,
Ordu University
52200 Ordu,
Turkey

varolcanakci@yahoo.com

Downloads

Published

02-03-2022

How to Cite

[1]
Turkmen Е., C. Gokmenoglu, C. Kara, F. Dede, H. Yılmaz, and V. Canakcı, “Effect of Non-surgical Periodontal Treatment on Lipoxin A4 Levels in Periodontitis Patients”, C. R. Acad. Bulg. Sci. , vol. 75, no. 2, pp. 287–294, Mar. 2022.

Issue

Section

Medicine