Sex-dependent Differences of Emotional Status in a Rat Model of Prenatal Stress

Authors

  • Natasha Ivanova Institute of Neurobiology, Bulgarian Academy of Sciences
  • Zlatina Nenchovska Institute of Neurobiology, Bulgarian Academy of Sciences
  • Milena Atanasova Department of Biology, Medical University of Pleven, Bulgaria
  • Rumyana Mitreva Institute of Neurobiology, Bulgarian Academy of Sciences
  • Tzveta Stoynova Institute of Neurobiology, Bulgarian Academy of Sciences
  • Lidia Kortenska Institute of Neurobiology, Bulgarian Academy of Sciences
  • Jana Tchekalarova Institute of Neurobiology, Bulgarian Academy of Sciences

DOI:

https://doi.org/10.7546/CRABS.2022.07.17

Keywords:

sex difference, anxiety, depression, rat, prenatal stress, corticosterone

Abstract

Untoward events during pregnancy negatively affect offspring mental development. We investigated sex-dependent differences of emotional problems in offspring with a history of prenatal stress (PNS). Female rats demonstrated decreased anxiety-like behaviour in comparison to male controls, shown in the light-dark test. Male and female offspring of prenatally stressed mothers were characterized by higher anxiety levels, compared to unstressed controls. PNS induced depression-like behaviour in both sexes without differences among them, indicated with decreased intake of sweet solution in the sucrose consumption tests and increased immobility time spent in the forced swim test. Control females showed higher plasma corticosteroid (CORT) concentrantions after acute stress and decreased recovery (120 min after the stressor) than control males. Both male and female PNS-offspring were with elevated levels of CORT in the plasma, which remained high 120 min after application of the stressogenic procedure. This study evidenced that the unfavourable effect of PNS on emotional state correlated with impaired feedback mechanism of the hypothalamic-pituitary-adrenal (HPA) axis function both in male and female offspring.

Author Biographies

Natasha Ivanova, Institute of Neurobiology, Bulgarian Academy of Sciences

Mailing Address:
Institute of Neurobiology,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 23
1113 Sofia, Bulgaria

E-mail: n.ivanova@inb.bas.bg

Zlatina Nenchovska, Institute of Neurobiology, Bulgarian Academy of Sciences

Mailing Address:
Institute of Neurobiology,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 23
1113 Sofia, Bulgaria

E-mail: z.nenchovska@inb.bas.bg

Milena Atanasova, Department of Biology, Medical University of Pleven, Bulgaria

Mailing Address:
Department of Biology,
Medical University of Pleven
1 St. Kliment Ohridski St
5800 Pleven, Bulgaria

E-mail: Milena.Atanasova-Radeva@mu-pleven.bg

Rumyana Mitreva, Institute of Neurobiology, Bulgarian Academy of Sciences

Mailing Address:
Institute of Neurobiology,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 23
1113 Sofia, Bulgaria

E-mail: r.mitreva@inb.bas.bg

Tzveta Stoynova, Institute of Neurobiology, Bulgarian Academy of Sciences

Mailing Address:
Institute of Neurobiology,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 23
1113 Sofia, Bulgaria

E-mail: t.stoyanova@inb.bas.bg

Lidia Kortenska, Institute of Neurobiology, Bulgarian Academy of Sciences

Mailing Address:
Institute of Neurobiology,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 23
1113 Sofia, Bulgaria

E-mail: l.kortenska@inb.bas.bg

Jana Tchekalarova, Institute of Neurobiology, Bulgarian Academy of Sciences

Mailing Address:
Institute of Neurobiology,
Bulgarian Academy of Sciences
Akad. G. Bonchev St, Bl. 23
1113 Sofia, Bulgaria

E-mail: jt.chekalarova@inb.bas.bg

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Published

29-07-2022

How to Cite

[1]
N. Ivanova, “Sex-dependent Differences of Emotional Status in a Rat Model of Prenatal Stress”, C. R. Acad. Bulg. Sci. , vol. 75, no. 7, pp. 1082–1088, Jul. 2022.

Issue

Section

Medicine